期刊
JOURNAL OF CELL SCIENCE
卷 125, 期 20, 页码 4770-4779出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.104059
关键词
Centrosomal satellite proteins; Cep131; AZI1; Genome stability
类别
资金
- Cancer Research UK (CR-UK)
- Yorkshire Cancer Research (YCR)
- Cancer Research UK [11581, 12102] Funding Source: researchfish
The centrosome acts as a centre for microtubule organisation and plays crucial roles in cell polarity, migration, growth and division. Cep131 has recently been described as a basal body component essential for cilium formation, but its function in non-ciliogenic cells is unknown. We identified human Cep131 (also known as AZI1) in a screen for regulators of genome stability. We show that centrosomal localisation of Cep131 is cell-cycle-regulated and requires both an intact microtubule network and a functional dynein-dynactin transport system. Cep131 is recruited to centriolar satellites by PCM1, and localised to the centriolar core region by both pericentrin and Cep290. Depletion of Cep131 results in a reduction in proliferation rate, centriole amplification, an increased frequency of multipolar mitosis, chromosomal instability and an increase in post-mitotic DNA damage. These data therefore highlight the importance of human Cep131 for maintaining genomic integrity.
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