期刊
JOURNAL OF CELL SCIENCE
卷 125, 期 20, 页码 4713-4719出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.107409
关键词
alpha-actinin; Cell division; Cleavage furrow positioning; Centralspindlin; Microtubule
类别
资金
- Temasek Life Sciences Laboratory
Proper positioning of the cleavage furrow is essential for successful cell division. The mitotic spindle, which consists of dynamic astral microtubules and stable equatorial microtubules is responsible for this process. However, little is known about how microtubules are regulated in a time- and region-dependent manner. Here, we show that alpha-actinin-regulated cortical actin filament integrity is crucial to specify different populations of microtubules during cell division in mammalian cells. Depletion of alpha-actinin caused aberrant recruitment of centralspindlin, but not aurora B or PRC1, to the tips of astral microtubules, leading to a stable association of astral microtubules with the cortex and induction of ectopic furrowing. Depletion of alpha-actinin also caused impaired assembly of midzone microtubules, leading to a failure of relocation of aurora B to midzone. Our findings unveil an unexpected yet crucial role for an actin crosslinking protein in the regulation of the localization of the microtubule-associated cytokinetic regulator.
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