期刊
JOURNAL OF CELL SCIENCE
卷 123, 期 15, 页码 2605-2612出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.067306
关键词
Cellular senescence; DNA damage; Nuclear lamins; Telomerase; Telomere dysfunction; Tumor suppressors
类别
资金
- NCI [PO1CA80058, T32 CA078207]
- New York State Stem Cell [C024313]
- NIGMS [T32 GM008553]
- NIH-NCI [5R24 CA095823-04]
- NSF [DBI-9724504]
- NIH [1 S10 RR0 9145-01]
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature-aging syndrome caused by a dominant mutation in the gene encoding lamin A, which leads to an aberrantly spliced and processed protein termed progerin. Previous studies have shown that progerin induces early senescence associated with increased DNA-damage signaling and that telomerase extends HGPS cellular lifespan. We demonstrate that telomerase extends HGPS cellular lifespan by decreasing progerin-induced DNA-damage signaling and activation of p53 and Rb pathways that otherwise mediate the onset of premature senescence. We show further that progerin-induced DNA-damage signaling is localized to telomeres and is associated with telomere aggregates and chromosomal aberrations. Telomerase amelioration of DNA-damage signaling is relatively rapid, requires both its catalytic and DNA-binding functions, and correlates in time with the acquisition by HGPS cells of the ability to proliferate. All of these findings establish that HGPS premature cellular senescence results from progerin-induced telomere dysfunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据