期刊
JOURNAL OF CELL SCIENCE
卷 123, 期 3, 页码 309-320出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.061739
关键词
Live-cell imaging; Macromolecular assemblies; Signal transduction
类别
资金
- MRC [G0700771] Funding Source: UKRI
- Medical Research Council [G0700771] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G0700771] Funding Source: Medline
Signalling molecules integrate, codify and transport information in cells. Organisation of these molecules in complexes and clusters improves the efficiency, fidelity and robustness of cellular signalling. Here, we summarise current views on how signalling molecules assemble into macromolecular complexes and clusters and how they use their physical properties to transduce environmental information into a variety of cellular processes. In addition, we discuss recent innovations in live-cell imaging at the sub-micrometer scale and the challenges of object (particle) tracking, both of which help us to observe signalling complexes and clusters and to examine their dynamic character.
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