期刊
JOURNAL OF CELL SCIENCE
卷 122, 期 14, 页码 2337-2350出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.028100
关键词
Calcium; Gene transcription; InsP(3); Nucleus; Paclitaxel; Ryanodine; Signalling; Spindle checkpoint; Taxol
类别
资金
- British Heart Foundation [PG/07/040, PG/06/034/20637] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/E/B/00001116, BBS/E/B/0000C116] Funding Source: researchfish
Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca2+) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca2+ activity, and vice versa. In this Commentary, we describe mechanisms of nuclear Ca2+ signalling and discuss what is known about the origin and physiological significance of nuclear Ca2+ transients. In particular, we focus on the idea that the nucleus has an autonomous Ca2+ signalling system that can generate its own Ca2+ transients that modulate processes such as gene transcription. We also discuss the role of nuclear pores and the nuclear envelope in controlling ion flux into the nucleoplasm.
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