期刊
JOURNAL OF CELL SCIENCE
卷 122, 期 21, 页码 3837-3850出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.056127
关键词
PIP5K1; PIP5K; PtdIns(4,5)P-2; Phosphatidylinositol; Phosphatidylinositol (4,5)-bisphosphate; Phosphatidylinositol 4-phosphate 5-kinase
类别
It has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P-2]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P-2 acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P-2 production, and discuss the role of these proteins in different cellular processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据