期刊
JOURNAL OF CELL SCIENCE
卷 122, 期 8, 页码 1059-1069出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.039446
关键词
Adhesion; Spreading; Engulfment; Migration; Invasion; Integrins; Rho-GTPases; Src-family kinases; Extracellular matrix; Mechanotransduction
类别
资金
- Dutch Cancer Society [UL 2003-2858]
Interactions between cells and the extracellular matrix coordinate signaling pathways that control various aspects of cellular behavior. Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly. In turn, this modulates signaling pathways that are triggered by various other transmembrane receptors and augments the cellular response to growth factors. Over the past years, it has become clear that there is extensive crosstalk between integrins, Src-family kinases and Rho-family GTPases at the heart of such adhesion signaling. In this Commentary, we discuss recent advances in our understanding of the dynamic regulation of the molecular connections between these three protein families. We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction.
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