期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 27, 期 2, 页码 300-304出版社
WILEY-BLACKWELL
DOI: 10.1111/nmo.12494
关键词
basal UES pressure; esophageal high-resolution manometry; landmark phase
资金
- Department of Internal Medicine, Washington University in St. Louis
BackgroundIntolerance of the esophageal manometry catheter may prolong high-resolution manometry (HRM) studies and increase patient distress. We assessed the impact of obtaining the landmark phase at the end of the study when the patient has acclimatized to the HRM catheter. Methods366 patients (mean age 55.40.8years, 62.0% female) undergoing esophageal HRM over a 1-year period were studied. The standard protocol consisted of the landmark phase, 10 5mL water swallows 20-30s apart, and multiple rapid swallows where 4-6 2mL swallows were administered in rapid succession. The modified protocol consisted of the landmark phase at the end of the study after test swallows. Study duration, technical characteristics, indications, and motor findings were compared between standard and modified protocols. Key ResultsOf the 366 patients, 89.6% underwent the standard protocol (study duration 12.9 +/- 0.3min). In 10.4% with poor catheter tolerance undergoing the modified protocol, study duration was significantly longer (15.6 +/- 1.0min, p=0.004) despite similar duration of study maneuvers. Only elevated upper esophageal sphincter basal pressures at the beginning of the study segregated modified protocol patients. The 95th percentile time to landmark phase in the standard protocol patients was 6.1min; as many as 31.4% of modified protocol patients could not obtain their first study maneuver within this period (p=0.0003). Interpretation was not impacted by shifting the landmark phase to the end of the study. Conclusions & InferencesModification of the HRM study protocol with the landmark phase obtained at the end of the study optimizes study duration without compromising quality.
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