期刊
JOURNAL OF CELL SCIENCE
卷 121, 期 20, 页码 3285-3292出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.023507
关键词
Mechanical force; Traction force; Mechanobiology; cell adhesion; Stiffness; Rigidity
类别
资金
- National Institutes of Health
- Army Research Office Multidisciplinary University Research Initiative
Mechanical stresses are ever present in the cellular environment, whether through external forces that are applied to tissues or endogenous forces that are generated within the active cytoskeleton. Despite the wide array of studies demonstrating that such forces affect cellular signaling and function, it remains unclear whether mechanotransduction in different contexts shares common mechanisms. Here, I discuss possible mechanisms by which applied forces, cell-generated forces and changes in substrate mechanics could exert changes in cell function through common mechanotransduction machinery. I draw from examples that are primarily focused on the role of adhesions in transducing mechanical forces. Based on this discussion, emerging themes arise that connect these different areas of inquiry and suggest multiple avenues for future studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据