期刊
JOURNAL OF CELL SCIENCE
卷 121, 期 5, 页码 609-617出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.025502
关键词
hair follicle; epidermis; upper isthmus; stem cell antigen 1; Tbc1d10c
类别
资金
- NCI NIH HHS [R01 CA114014] Funding Source: Medline
- NIAMS NIH HHS [P30 AR044535, P30 AR044535-09] Funding Source: Medline
The bulge region of adult murine hair follicles harbors epidermal stem cells with multipotent capacity; however, the restricted contributions of these cells under homeostatic conditions indicates that additional stem or progenitor cell populations may be required to maintain squamous and sebaceous lineages. We have identified a distinct population of murine hair follicle keratinocytes residing in the upper isthmus (UI) between the infundibulum and bulge regions that are distinguished by low alpha 6 integrin levels and are negative for CD34 and Sca-1. Purified UI cells give rise to long-term, stable epidermal, follicular and sebaceous lineages and can self-renew in vivo. These cells are non-quiescent and possess a unique transcript profile compared with bulge stem cells and may represent a distinct reservoir of epidermal stem or progenitor cells.
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