期刊
JOURNAL OF CELL SCIENCE
卷 121, 期 17, 页码 2951-2960出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.025684
关键词
unitary synapse; synaptic plasticity; interneuron; action potential; spike timing; calcineurin; Ca2+-calmodulin.
类别
资金
- National Award for Outstanding Young Scientist [30325021]
- Natural Science Foundation of China [NSFC 30470362, 30621130077]
- National Basic Research Program [2006CB500804, 2006CB911003]
- CAS Program for Innovation [KSCX2-YWR-39]
Neuronal spike encoding and synaptic transmission in the brain need be precise and reliable for well-organized behavior and cognition. Little is known about how a unitary synapse reliably transmits presynaptic sequential spikes and how multiple unitary synapses precisely drive their postsynaptic neurons to encode spikes. To address these questions, we investigated the dynamics of glutamatergic unitary synapses as well as their role in driving the encoding of cortical fast-spiking neurons. Synaptic transmission patterns randomly fluctuate among facilitation, depression and parallel over time. The postsynaptic calmodulin-signaling pathway enhances initial responses and converts this fluctuation to a synaptic depression. We integrated current pulses mathematically based on synaptic plasticity and found that they improve spike capacity and timing precision by shortening the spike refractory period at postsynaptic neurons. Our results indicate that the gain and fidelity of synaptic patterns enable reliable transmission of presynaptic signals by the synapse and precise encoding of spikes by postsynaptic neurons. These reproducible neural codes may be involved in controlling well-organized behavior.
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