期刊
JOURNAL OF CELL BIOLOGY
卷 206, 期 1, 页码 113-127出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201402093
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资金
- Medical Research Council [MR/J000655/1]
- Biotechnology and Biological Sciences Research Council
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) (KAKENHI) [25111702]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [24700962]
- Uehara memorial foundation
- Asahi Glass foundation
- JSPS KAKENHI [25290042]
- Wellcome Trust
- Royal Society University Research fellowship
- Biotechnology and Biological Sciences Research Council [BB/F019769/1]
- BBSRC [BB/D017521/1, BB/F019769/1] Funding Source: UKRI
- EPSRC [EP/F058586/1] Funding Source: UKRI
- MRC [G0801145, G117/506, MR/J000655/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D017521/1, BB/F019769/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/F058586/1] Funding Source: researchfish
- Medical Research Council [G117/506, MR/J000655/1, G0801145] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [24700962, 25111702] Funding Source: KAKEN
Collective cell migration (CCM) and epithelial-mesenchymal transition (EMT) are common to cancer and morphogenesis, and are often considered to be mutually exclusive in spite of the fact that many cancer and embryonic cells that have gone through EMT still cooperate to migrate collectively. Here we use neural crest (NC) cells to address the question of how cells that have down-regulated cell-cell adhesions can migrate collectively. NC cell dissociation relies on a qualitative and quantitative change of the cadherin repertoire. We found that the level of cell-cell adhesion is precisely regulated by internalization of N-cadherin downstream of lysophosphatidic acid (LPA) receptor 2. Rather than promoting the generation of single, fully mesenchymal cells, this reduction of membrane N-cadherin only triggers a partial mesenchymal phenotype. This intermediate phenotype is characterized by an increase in tissue fluidity akin to a solid-like-to-fluid-like transition. This change of plasticity allows cells to migrate under physical constraints without abolishing cell cooperation required for collectiveness.
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