期刊
JOURNAL OF CELL BIOLOGY
卷 206, 期 5, 页码 579-588出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201404124
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资金
- National Institutes of Health [R01CA133662, RO1CA1 38212, RC4CA156509, R01CA96865]
The partitioning of intracellular space beyond membrane-bound organelles can be achieved with collections of proteins that are multivalent or contain low-complexity, intrinsically disordered regions. These proteins can undergo a physical phase change to form functional granules or other entities within the cytoplasm or nucleoplasm that collectively we term assemblage. Intrinsically disordered proteins (IDPs) play an important role in forming a subset of cellular assemblages by promoting phase separation. Recent work points to an involvement of assemblages in disease states, indicating that intrinsic disorder and phase transitions should be considered in the development of therapeutics.
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