期刊
JOURNAL OF CELL BIOLOGY
卷 203, 期 1, 页码 23-33出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201303110
关键词
-
类别
资金
- National Cancer Institute Cancer Pharmacology grant [R25 CA101871]
Stem cells exert precise regulation to maintain a balance of self-renewal and differentiation programs to sustain tissue homeostasis throughout the life of an organism. Recent evidence suggests that this regulation is modulated, in part, via metabolic changes and modifications of nutrient-sensing pathways such as mTOR and AMPK. It is becoming increasingly clear that stem cells inhibit oxidative phosphorylation in favor of aerobic glycolysis for energy production. Recent progress has detailed the molecular mechanisms of this metabolic phenotype and has offered insight into new metabolic pathways that may be involved in stem cell homeostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据