期刊
JOURNAL OF CELL BIOLOGY
卷 197, 期 7, 页码 857-867出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201110131
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资金
- National Institutes of Health [P01 HL057346, R37 DK042394, R01 DK088227, R24 DK093074, R01 HL052173]
- American Heart Association
A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and secretory activities in the cell. Alterations in ER homeostasis cause accumulation of misfolded/unfolded proteins in the ER. To maintain ER homeostasis, eukaryotic cells have evolved the unfolded protein response (UPR), an essential adaptive intracellular signaling pathway that responds to metabolic, oxidative stress, and inflammatory response pathways. The UPR has been implicated in a variety of diseases including metabolic disease, neurodegenerative disease, inflammatory disease, and cancer. Signaling components of the UPR are emerging as potential targets for intervention and treatment of human disease.
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