期刊
JOURNAL OF CELL BIOLOGY
卷 198, 期 3, 页码 281-293出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201202014
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资金
- BioRN Spitzencluster Molecular and Cell based Medicine
- German Bundesministerium fur Bildung und Forschung (BMBF)
- EU-FP7 Program
- Deutsche Forschungsgemeinschaft (DFG) [SFB 873]
- Dietmar Hopp Foundation
The cancer stem cell (CSC) concept, which arose more than a decade ago, proposed that tumor growth is sustained by a subpopulation of highly malignant cancerous cells. These cells, termed CSCs, comprise the top of the tumor cell hierarchy and have been isolated from many leukemias and solid tumors. Recent work has discovered that this hierarchy is embedded within a genetically heterogeneous tumor, in which various related but distinct subclones compete within the tumor mass. Thus, genetically distinct CSCs exist on top of each subclone, revealing a highly complex cellular composition of tumors. The CSC concept has therefore evolved to better model the complex and highly dynamic processes of tumorigenesis, tumor relapse, and metastasis.
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