期刊
JOURNAL OF CELL BIOLOGY
卷 196, 期 5, 页码 553-562出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201105099
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资金
- National Institutes of Health [R01-HD043403]
- National Science Foundation [IOS-0744689]
Regeneration of complex structures after injury requires dramatic changes in cellular behavior. Regenerating tissues initiate a program that includes diverse processes such as wound healing, cell death, dedifferentiation, and stem (or progenitor) cell proliferation; furthermore, newly regenerated tissues must integrate polarity and positional identity cues with preexisting body structures. Gene knockdown approaches and transgenesis-based lineage and functional analyses have been instrumental in deciphering various aspects of regenerative processes in diverse animal models for studying regeneration.
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