期刊
JOURNAL OF CELL BIOLOGY
卷 198, 期 4, 页码 481-489出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201206050
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资金
- National Institutes of Health [R01 GM079139]
- American Heart Association [10POST3870021]
- National Center for Research Resources of the National Institutes of Health [C06 RR16490]
Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases ( MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge.
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