期刊
JOURNAL OF CELL BIOLOGY
卷 199, 期 7, 页码 1057-1066出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201207180
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资金
- Plan Nacional [BFU2008-00414]
- Consolider [CSD2009-00016]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) Grups de Recerca Emergents [SGR2009-1488]
- European Research Council [268692]
- Emmy Noether fellowship of the Deutsche Forschungsgemeinschaft (DFG) [BL 1186/1-1]
- ICREA Academia Award
- Spanish ministry of Science and Innovation [SAF2012-38140]
- Fondo de Investigacion Sanitaria [RD12/0042/0014]
- FEDER Funds
- Generalitat de Catalunya [SGR05-266]
- European Union
- ICREA Funding Source: Custom
Ca2+ import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca2+ retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca2+ import into the TGN; it binds secretory cargo in a Ca2+-dependent reaction and is required for its sorting at the TGN.
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