期刊
JOURNAL OF CELL BIOLOGY
卷 195, 期 5, 页码 709-720出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201102131
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- NHLBI NIH HHS [R01 HL092471] Funding Source: Medline
Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells. Because HSCs must persist for a lifetime, the balance between their proliferation and quiescence is carefully regulated to ensure blood homeostasis while limiting cellular damage. Cell cycle regulation therefore plays a critical role in controlling HSC function during both fetal life and in the adult. The cell cycle activity of HSCs is carefully modulated by a complex interplay between cell-intrinsic mechanisms and cell-extrinsic factors produced by the microenvironment. This fine-tuned regulatory network may become altered with age, leading to aberrant HSC cell cycle regulation, degraded HSC function, and hematological malignancy.
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