期刊
JOURNAL OF CELL BIOLOGY
卷 195, 期 6, 页码 943-952出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201105019
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资金
- National Institutes of Health [AI41699, AI64559]
- Anna Fuller Postdoctoral Fellowship Award
- European Molecular Biology Organization
Mammalian phagocytes control bacterial infections effectively through phagocytosis, the process by which particles engulfed at the cell surface are transported to lysosomes for destruction. However, intracellular pathogens have evolved mechanisms to avoid this fate. Many bacterial pathogens use specialized secretion systems to deliver proteins into host cells that subvert signaling pathways controlling membrane transport. These bacterial effectors modulate the function of proteins that regulate membrane transport and alter the phospholipid content of membranes. Elucidating the biochemical function of these effectors has provided a greater understanding of how bacteria control membrane transport to create a replicative niche within the host and provided insight into the regulation of membrane transport in eukaryotic cells.
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