期刊
JOURNAL OF CELL BIOLOGY
卷 193, 期 2, 页码 257-266出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201010131
关键词
-
类别
资金
- National Institutes of Health [R37 AG23806, R01 AR056849]
- Glenn Foundation for Medical Research
- Department of Veterans Affairs
- American Federation for Aging Research
Adult stem cells exist in most mammalian organs and tissues and are indispensable for normal tissue homeostasis and repair. In most tissues, there is an age-related decline in stem cell functionality but not a depletion of stem cells. Such functional changes reflect deleterious effects of age on the genome, epigenome, and proteome, some of which arise cell autonomously and others of which are imposed by an age-related change in the local milieu or systemic environment. Notably, some of the changes, particularly epigenomic and proteomic, are potentially reversible, and both environmental and genetic interventions can result in the rejuvenation of aged stem cells. Such findings have profound implications for the stem cell-based therapy of age-related diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据