期刊
JOURNAL OF CELL BIOLOGY
卷 191, 期 4, 页码 875-890出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201004154
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资金
- German Ministry of Education and Research [BMBF 0311889]
- German Research Association (DFG) [KO1949/31]
- Studienstiftang des deutschen Volkes
- Natural Sciences and Engineering Research Council (NSERC) of Canada
The position of the centrosome ahead of the nucleus has been considered crucial for coordinating neuronal migration in most developmental situations The proximity of the centrosome has also been correlated with the site of axonogenesis in certain differentiating neurons Despite these positive correlations, accumulating experimental findings appear to negate a universal role of the centrosome in determining where an axon forms, or in leading the migration of neurons To further examine this controversy in an in vivo setting, we have generated cell type specific multi-cistronic gene expression to monitor subcellular dynamics in the developing zebrafish cerebellum We show that migration of rhombic lip derived neurons is characterized by a centrosome that does not persistently lead the nucleus, but which is Instead regularly overtaken by the nucleus In addition, axonogenesis is initiated during the onset of neuronal migration and occurs independently of centrosome proximity These in vivo data reveal a new temporal orchestration of or ganelle dynamics and provide important insights into the variation in intracellular processes during vertebrate brain differentiation
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