4.7 Article

Discrete PIH proteins function in the cytoplasmic preassembly of different subsets of axonemal dyneins

期刊

JOURNAL OF CELL BIOLOGY
卷 190, 期 1, 页码 65-71

出版社

ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201002081

关键词

-

资金

  1. Ministry of Education, Culture, Sports, Science and Technology [20051007]
  2. Japan Society for the Promotion of Science
  3. Grants-in-Aid for Scientific Research [20051007, 21370088] Funding Source: KAKEN

向作者/读者索取更多资源

Axonemal dyneins are preassembled in the cytoplasm before being transported into cilia and flagella. Recently, PF13/KTU, a conserved protein containing a PIH (protein interacting with HSP90) domain, was identified as a protein responsible for dynein preassembly in humans and Chlamydomonas reinhardtii. This protein is involved in the preassembly of outer arm dynein and some inner arm dyneins, possibly as a cofactor of molecular chaperones. However, it is not known which factors function in the preassembly of other inner arm dyneins. Here, we analyzed a novel C. reinhardtii mutant, ida10, and found that another conserved PIH family protein, MOT48, is responsible for the formation of another subset of inner arm dyneins. A variety of organisms with motile cilia and flagella typically have three to four PIH proteins, including potential homologues of MOT48 and PF13/KTU, whereas organisms without them have no, or only one, such protein. These findings raise the possibility that multiple PIH proteins are commonly involved in the preassembly of different subsets of axonemal dyneins.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据