期刊
JOURNAL OF CELL BIOLOGY
卷 186, 期 4, 页码 461-472出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200906068
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- Muscular Dystrophy Association
- National Institutes of Health [1R01GM084204]
- Research to Prevent Blindness, Inc. [34821]
- National Institutes of Health Vision Core [P30 EY 02687]
The nucleus is the most prominent cellular organelle, and its sharp boundaries suggest the compartmentalization of the nucleoplasm from the cytoplasm. However, the recent identification of evolutionarily conserved linkers of the nucleoskeleton to the cytoskeleton (LINC) complexes, a family of macromolecular assemblies that span the double membrane of the nuclear envelope, reveals tight physical connections between the two compartments. Here, we review the structure and evolutionary conservation of SUN and KASH domain-containing proteins, whose interaction within the perinuclear space forms the nuts and bolts of LINC complexes. Moreover, we discuss the function of these complexes in nuclear, centrosomal, and chromosome dynamics, and their connection to human disease.
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