相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
Hyunkyung Jeong et al.
CELL (2009)
Phosphorylation of Threonine 3 IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY
Charity T. Aiken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process
Ayako Tonoki et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
Simon C. Warby et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2009)
Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
Xiaofeng Gu et al.
NEURON (2009)
IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin
Ali Khoshnan et al.
PLOS ONE (2009)
Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK
Han C. Dan et al.
GENES & DEVELOPMENT (2008)
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
Simon C. Warby et al.
HUMAN MOLECULAR GENETICS (2008)
Proteasome activation as a novel antiaging strategy
Niki Chondrogianni et al.
IUBMB LIFE (2008)
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Maria Bjorkqvist et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity
Amber L. Southwell et al.
JOURNAL OF NEUROSCIENCE (2008)
Characterization of the Human COP9 Signalosome Complex Using Affinity Purification and Mass Spectrometry
Lei Fang et al.
JOURNAL OF PROTEOME RESEARCH (2008)
CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice
Barbara L. Apostol et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2008)
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
Cong Zhang et al.
NATURE MEDICINE (2008)
Characterization of the proteasome interaction network using a QTAX-based tag-team strategy and protein interaction network analysis
Cortnie Guerrero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The age of crosstalk: Phosphorylation, ubiquitination, and beyond
Tony Hunter
MOLECULAR CELL (2007)
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
Randy Singh Atwal et al.
HUMAN MOLECULAR GENETICS (2007)
Polyglutamine diseases: emerging concepts in pathogenesis and therapy
Jieya Shao et al.
HUMAN MOLECULAR GENETICS (2007)
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
Sandrine L. Anne et al.
JOURNAL OF NEUROSCIENCE (2007)
SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock
Ray-Chang Wu et al.
CELL (2007)
Proinflammatory stimuli induce IKKα-mediated phosphorylation of PIAS1 to restrict inflammation and immunity
Bin Liu et al.
CELL (2007)
Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB
Wei-Chien Huang et al.
MOLECULAR CELL (2007)
Parkin mediates neuroprotection through activation of IκB kinase/nuclear factor-κB signaling
Iris H. Henn et al.
JOURNAL OF NEUROSCIENCE (2007)
The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis
Erica Rockabrand et al.
HUMAN MOLECULAR GENETICS (2007)
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation
Elisabetta Zuccato et al.
JOURNAL OF CELL SCIENCE (2007)
Autophagy and neurodegeneration: when the cleaning crew goes on strike
Marta Martinez-Vicente et al.
LANCET NEUROLOGY (2007)
Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
Susmita Kaushik et al.
EMBO JOURNAL (2006)
Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1
Angel Hernandez-Hernandez et al.
EMBO JOURNAL (2006)
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
Rona K. Graham et al.
CELL (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function
Anat Yanai et al.
NATURE NEUROSCIENCE (2006)
Consequences of the selective blockage of chaperone-mediated autophagy
AC Massey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A tandem affinity tag for two-step purification under fully denaturing conditions -: Application in ubiquitin profiling and protein complex identification combined with in vivo cross-linking
C Tagwerker et al.
MOLECULAR & CELLULAR PROTEOMICS (2006)
PDSM, a motif for phosphorylation-dependent SUMO modification
V Hietakangas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches
C Peters-Libeu et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2005)
Autophagy and aging -: The importance of maintaining clean cells
Ana Maria Cuervo et al.
AUTOPHAGY (2005)
NF-κB RelA phosphorylation regulates RelA acetylation
LF Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo
SC Warby et al.
HUMAN MOLECULAR GENETICS (2005)
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
SQ Luo et al.
JOURNAL OF CELL BIOLOGY (2005)
Automated microscope system for determining factors that predict neuronal fate
M Arrasate et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Polyglutamine expansion of huntingtin impairs its nuclear export
J Cornett et al.
NATURE GENETICS (2005)
IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
MCT Hu et al.
CELL (2004)
SUMO modification of Huntingtin and Huntington's disease pathology
JS Steffan et al.
SCIENCE (2004)
Nuclear role of IκB kinase-γ/NF-κB essential modulator (IKKγ/NEMO) in NF-κB-dependent gene expression
UN Verma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Activation of the IκB kinase complex and nuclear factor-κB contributes to mutant Huntingtin neurotoxicity
A Khoshnan et al.
JOURNAL OF NEUROSCIENCE (2004)
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
M Arrasate et al.
NATURE (2004)
Polyubiquitination of p53 by a ubiquitin ligase activity of p300
SR Grossman et al.
SCIENCE (2003)
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves huntingtin phosphorylation by Akt
S Humbert et al.
DEVELOPMENTAL CELL (2002)
NF-κB in cancer:: From innocent bystander to major culprit
M Karin et al.
NATURE REVIEWS CANCER (2002)
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
TG Hofmann et al.
NATURE CELL BIOLOGY (2002)
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
G D'Orazi et al.
NATURE CELL BIOLOGY (2002)
CHIP is a U-box-dependent E3 ubiquitin ligase -: Identification of Hsc70 as a target for ubiquitylation
JH Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
JS Steffan et al.
NATURE (2001)
Age-related decline in chaperone-mediated autophagy
AM Cuervo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The heat shock protein Ssa2p is required for import of fructose-1,6-bisphosphatase into Vid vesicles
CR Brown et al.
JOURNAL OF CELL BIOLOGY (2000)
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
JS Steffan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
分享论文
