期刊
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
卷 35, 期 8, 页码 1358-1362出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcrs.2009.03.035
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PURPOSE: To evaluate the complication rate of corneal crosslinking (CXL) for primary keratectasia and to develop recommendations for avoiding complications. SETTING: Institut fur Refraktive und Ophthalmo-Chirurgie, Zurich, Switzerland. METHODS: In a prospective study, eyes with verified progressive keratectasia had standard CXL. Preoperative and 6- and 12-month postoperative examinations included corrected distance visual acuity (CDVA), slitlamp evaluation, applanation tonometry, and Scheimpflug imaging (Pentacam). Statistical analysis included analysis of variance and the Mann-Whitney U test to detect risk factors for complications. RESULTS: The study evaluated 117 eyes of 99 patients; approximately 90% completed the 12-month follow-up. The complication rate (percentage of eyes losing 2 or more Snellen lines) was 2.9% (95% confidence interval, 0.6%-8.5%). The failure rate of CXL (percentage of eyes with continued progression) was 7.6%. Age older than 35 years and a preoperative CDVA better than 20/25 were identified as significant risk factors for complications. A high preoperative maximum keratometry (K) reading was a significant risk factor for failure. Sterile infiltrates were seen in 7.6% of eyes and central stromal scars, in 2.8%. CONCLUSIONS: Results indicate that changing the inclusion criteria may significantly reduce the complications and failures of CXL.. A preoperative maximum K reading less than 58.00 diopters may reduce the failure rate to less than 3%, and restricting patient age to younger than 35 years may reduce the complication rate to 1%. J Cataract Refract Surg 2009,- 35:1358-1362 (C) 2009 ASCRS and ESCRS
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