期刊
JOURNAL OF CATALYSIS
卷 258, 期 2, 页码 289-295出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcat.2008.07.005
关键词
nitroaldol condensation; Michael addition; heterogeneous catalysis; organic-inorganic hybrid composites; supported catalysts; continuous-flow processes
资金
- MUR
A continuous-flow two-step process for the production of multifunctional intermediate compounds was performed with a combination of two column reactors packed with different organic immobilized catalysts. The first step of the reaction, nitroaldol condensation between aromatic aldehydes and nitromethane, is promoted by a silica gel-supported primary amine; the second step, Michael addition of beta-dicarbonyl compounds to the nitrostyrenes obtained in the first step, is catalyzed by a silica gel-supported guanidine TBD. In both cases, the catalysts can be directly reused for several runs with no significant changes in activity. (C) 2008 Elsevier Inc. All rights reserved.
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