期刊
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
卷 61, 期 6, 页码 461-470出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0b013e31828c0933
关键词
mechanosensors; mechanotransduction; endothelial cells and endothelium; shear stress; vascular function
资金
- Chinese National Program for Fundamental Research and Development (973 Program) [2012CB517803]
- National Natural Science Foundation of China [81270340, 81070217]
- Post-doctoral Science Foundation of China [2012M520775]
Vascular endothelial cells (ECs) line the luminal surface of blood vessels, which are exposed constantly to mechanical stimuli, such as fluid shear stress, cyclic strain, and blood pressure. In recent years, more and more evidence indicates that ECs sense these mechanical stimuli and subsequently convert mechanical stimuli into intracellular signals. The properties of ECs that sense the mechanical stimuli are defined as mechanosensors. There are a variety of mechanosensors that have been identified in ECs. These mechanosensors play an important role in regulating the function of the endothelium and vascular function, including blood pressure. This review focuses on the mechanosensors that have been identified in ECs and on the roles that mechanosensors play in the regulation of endothelium function, and in the regulation of vascular function.
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