期刊
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
卷 26, 期 1, 页码 1-6出版社
WILEY-BLACKWELL
DOI: 10.1111/jce.12504
关键词
arrhythmias; atrial fibrillation; caffeine; electrophysiology testing; supraventricular tachycardia
Study of Caffeine in Patients with Supraventricular Tachycardia IntroductionPatients with cardiac arrhythmias are generally instructed to avoid caffeine intake. A comprehensive evaluation of the electrophysiological effects of caffeine on atrial and ventricular tissues in humans has not previously been performed. Methods and ResultsEighty patients (31men, mean age 4914years) with symptomatic supraventricular tachycardia (SVT) undergoing an electrophysiologic study (EPS) prior to catheter ablation were randomized to receive oral caffeine or placebo. Caffeine at a dosage of 5mg/kg (moderate intake) or placebo tablets were administered orally at a mean time of 57 +/- 13 minutes prior to the EPS. The median (IQR) caffeine level in patients receiving caffeine was 7.4g/mL (4.7-8.7), as compared with 0.15 (0.00-0.61) in patients receiving placebo, P<0.0001. Caffeine was associated with a significant increase in resting systolic and diastolic blood pressures as compared with placebo, while the resting heart rate was not significantly different between both groups. Caffeine was not associated with significant effects on the effective refractory period of the atrium or ventricle, as well as on AV node conduction. SVT was induced in all but 3 patients; there was no significant difference between groups receiving placebo or caffeine on SVT inducibility or the cycle length of induced tachycardias. ConclusionsCaffeine, at moderate intake, was associated with significant increases in systolic and diastolic blood pressures, but had no evidence of a significant effect on cardiac conduction and refractoriness. Furthermore, no effect of caffeine on SVT induction or more rapid rates of induced tachycardias was found.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据