期刊
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
卷 28, 期 2, 页码 328-335出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.jvca.2013.05.008
关键词
cerebral circulation; blood-brain barrier; neurologic injury; cardiac surgery; cardiopulmonary bypass; brain venous pressure; S100 beta protein; matrix metalloproteinase 9; creatine kinase
Objective: Disturbances in venous outflow from the cerebral circulation may result in brain injury. Severe increases in brain venous pressure lead to brain ischemia and, subsequently, brain edema and intracranial hemorrhages. The purpose of this study was to determine the effect of changes in jugular venous bulb pressure (JVBP) on plasma blood brain-barrier biomarkers concentration and disturbances in arteriovenous total and ionized magnesium ((a-v)tMg and (a-v)iMg) in brain circulation in patients undergoing coronary artery bypass grafting surgery (CABG) with cardiopulmonary bypass (CPB). Design: Prospective observational study. Setting: Department of Cardiac Surgery at a Medical University Hospital. Participants: Ninety-two adult patients undergoing elective CABG with CPB under general anaesthesia were studied. Methods: Central venous pressure (CVP) was measured using a pulmonary artery catheter. The right jugular vein was cannulized retrogradely for jugular venous bulb pressure (JVBP) measurement. Concentrations of plasma S100 beta protein, matrix metalloproteinase 9 (MMP-9), creatine kinase isoenzyme BB (CK-BB) (a-v)tMg and (a-v)iMg were measured as the markers of blood-brain barrier dysfunction. All of them were analyzed in comparison with JVBP during surgery and the early postoperative period. Results: Elevated JVBP was noted after CPB and after surgery. Its increase above 12 mmHg intensified release of S100 beta, MMP-9 and CK-BB as well as disorders in (a-v)tMg and (a-v)iMg. CVP correlated with JVBP, S100 beta, and MMP-9. Moreover, JVBP correlated with S100 beta and MMP-9. Conclusions: Cardiac surgery increased JVBP, and JVBP elevated above 12 mmHg intensified an increase in bio-markers of plasma blood-brain barrier disruption. (C) 2014 Elsevier Inc. All rights reserved.
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