期刊
NEUROCHEMICAL RESEARCH
卷 40, 期 12, 页码 2615-2627出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-015-1519-z
关键词
Aquaporin; Water transport; Astrocyte; K+ clearance; Edema formation
资金
- Lundbeck Foundation
- Danish Medical Research Council
- Novo Nordic Foundation
- Lundbeck Foundation [R44-2009-4181] Funding Source: researchfish
Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K+ clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K+ clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据