期刊
NEUROCHEMICAL RESEARCH
卷 40, 期 9, 页码 1786-1791出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-015-1676-0
关键词
Cerebral ischemia; Inflammation; T cell; SIID
资金
- National Natural Science Foundation of China [81301019]
- American Heart Association [14FTF19970029]
Stroke results in cerebral inflammation that causes brain injury and triggers immunodepression, resulting in an increased incidence of morbidity and mortality secondary to remote infection. It is well known that T cells modulate brain inflammation after ischemic stroke, and targeting T cells may be an innovative therapeutic strategy for stroke treatment. T cell deficiency is neuro-protective, but the observed protective effects differ between ischemic models. Recent studies suggest different T cell subsets may have distinct effects on the injured brain. In addition to their role in cerebral inflammation, T cells also play a role in stroke-induced immunodepression. Therefore, T cell-targeted therapies designed to provide protection against brain inflammation might paradoxically contribute to remote organ infection and mortality. Further investigations are required to determine the role of specific T cell subsets in cerebral inflammation and stroke-induced immunodepression, the optimal therapeutic window for treatment, and the appropriate dose of anti-T cell therapy.
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