期刊
JOURNAL OF CARDIAC FAILURE
卷 16, 期 1, 页码 55-60出版社
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2009.07.002
关键词
Kidney function; cystatin C; arrhythmias; elderly; epidemiology
资金
- National Heart, Lung, and Blood Institute [N01-HC-35129, N01-HC-45133, N01-HC-75150, N01-HC-85079, N01-HC-85086, N01 HC-15103, N01 HC-55222, U01 HL080295]
- DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS [N01HC085082, N01HC085084, N01HC045133, N01HC085079, N01HC085080, N01HC085086, N01HC085083, N01HC055222, N01HC015103, N01HC085085, N01HC085081, N01HC075150, N01HC035129] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL080295] Funding Source: NIH RePORTER
Background: Impaired kidney function is associated with increased risk for cardiovascular events. We evaluated whether kidney function is associated with atrial fibrillation (AF) risk in elderly persons. Methods and Results: Subjects were participants in the Cardiovascular Health Study (CHS), a population-based cohort of ambulatory elderly. Measures of kidney function were cystatin C and creatinine-based estimated glomerular filtration rate (eGFR). Among the 4663 participants, 342 (7%) had AF at baseline and 579 (13%) developed incident AF during follow-up (mean 7.4 years). In unadjusted analyses, cystatin C quartiles were strongly associated with prevalent AF with a nearly 3-fold odds in the highest quartile compared with the lowest (HR = 1.19, 95% CI [0.80-1.76] in quartile 2; FIR = 2.00, 95% Cl [1.38-2.88] in quartile 3; and FIR = 2.87, 95% Cl [2.03-4.07] in quartile 4). This increased risk for prevalent AF remained significant after multivariate adjustment. The risk for incident AF increased across cystatin C quartiles in the unadjusted analysis (HR = 1.37, 95% Cl [1.07-1.75] in quartile 2; HR = 1.43, 95% CI [1.11-1.84] in quartile 3; and HR = 1.88, 95% Cl [1.47-2.41] in quartile 4); however, after multivariate adjustment, these findings were no longer significant. An estimated GFR <60 mL . min . 1.73 m(2) was associated with prevalent and incident AF in unadjusted, but not multivariate analyses. Conclusions: Impaired kidney function, as measured by cystatin C, is an independent marker of prevalent AF; however, neither cystatin C nor eGFR are predictors of incident AF. (J Cardiac Fail 2010:16:55-60)
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