期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 124, 期 -, 页码 48-51出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2015.04.009
关键词
Hippocampus; Memory; Synaptic plasticity; Synaptic signaling
资金
- MRC
- BBSRC
- BBSRC [BB/J021423/1, BB/I020330/1, BB/J021687/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J021687/1, BB/J021423/1, BB/I020330/1] Funding Source: researchfish
NMDA receptor-dependent long-term potentiation (LTP) at hippocampal CA1 synapses is a well-accepted mechanism underlying long-term memory (LTM) formation. However, studies with mice that lack threonine-286 autophosphorylation of alpha CaMKII have shown that hippocampal LTM can be formed despite absence of NMDA receptor-dependent CA1 LTP. After multiple training trials, LTM formation in these mutants is linked to the generation of multi-innervated dendritic spines (MIS), a spine that receives typically two presynaptic inputs. PSD-95 overexpression is sufficient for MIS generation and depends on mTOR signaling. LTM that involves MIS generation appears less modifiable upon retrieval in comparison to LTM without MIS generation. Taken together, MIS generation appears to be a novel LTM mechanism after multiple training trials, which may occur in diseases with impaired LTP or conditions affecting negative feedback CaMKII signaling at the synapse. (C) 2015 The Authors. Published by Elsevier Inc.
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