期刊
JOURNAL OF CARBOHYDRATE CHEMISTRY
卷 32, 期 1, 页码 1-43出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07328303.2012.749264
关键词
Glycosylation; Leaving group; Activation; Oligosaccharides; Reaction mechanism
资金
- National Science Foundation [CHE-1058112]
- National Institute of General Medical Studies [GM077170]
Many glycosyl donors used in chemical glycosylation are too stable to undergo spontaneous glycosylation. Hence, the first key step of practically every glycosylation reaction is the activation of the leaving group that usually takes place via its interaction with a promoter/activator or, more rarely, a catalyst. The focus of this review is the first key step of glycosylation with the emphasis on the modes by which the leaving groups are activated and departed. Studies wherein the exact nature of the activation process has been reliably elucidated are still scarce. Therefore, this review particularly details the mechanistic studies wherein the mode of activation was proven either by characterizing the activated intermediates or by isolation of the departed leaving groupactivator adducts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据