期刊
JOURNAL OF CARBOHYDRATE CHEMISTRY
卷 31, 期 1-3, 页码 67-92出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07328303.2012.654553
关键词
Polymer; Glycopolymer; Polymerization; Chain-end functionalization Protein; Lectin; Glycomicroarry
资金
- NIH [1R01HL102604-02]
- Ohio Research Scholar Program
- NSF MRI [CHE-1126384]
Glycopolymers as multivalent clusters of carbohydrate derivatives have been proven effective tools in the study of carbohydrate-based biological processes and have shown great potential in biomedical applications. It has been found that the shape and size of glycopolymers, as well as the density and relative positioning of their glycan appendages, are very important regarding their effectiveness in bio-interactions. Recently, a variety of chain-end functionalized polymers have been explored for the preparation of structurally well-defined glycopolymers that have potential protein modification and microarray fabrication applications. This review summarizes recent advances in the synthesis and biomedical applications of chain-end functionalized glycopolymers.
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