期刊
JOURNAL OF CARBOHYDRATE CHEMISTRY
卷 31, 期 4-6, 页码 384-419出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07328303.2012.658274
关键词
Sulfated carbohydrates; Solid-phase synthesis; Protecting groups; Glycosaminoglycans; Heparan sulfate
资金
- National Institutes of Health [GM-06982]
Mono- and disaccharides of sulfonated glucosamines (GlcN sulfoforms) conjugated to 2-aminoethyl linkers were generated by solid-phase synthesis. Orthogonally protected intermediates were tethered onto tritylated polystyrene resin beads, subjected to a modular sequence of deprotection and sulfonation steps, then cleaved from solid support without degradation of N- or O-sulfate esters using solvolytic conditions, and finally purified by reverse-phase HPLC to afford the title compounds.
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