期刊
JOURNAL OF CARBOHYDRATE CHEMISTRY
卷 27, 期 5, 页码 279-293出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07328300802218713
关键词
trityl ethers; regioselective reactions; ball mill; solvent-free synthesis; mechanochemical reactions
Dry ball milling of hexosides with trityl chloride in the presence of DABCO or Na2CO3 has been found to result in their complete conversion to the respective 6-O-trityl ethers. Further wet grinding of the reaction mixture with Ac2O in the presence of DMAP led to the respective fully protected hexosides in good to excellent yields after isolation. It has been found to be an effective one-pot two-step synthesis under solvent-free condition. The speed of homogenization has been shown to highly influence the rate and outcome of the reaction, and commercially available planetary ball mill has been proved to be very convenient for carrying out the reaction under standardized and reproducible conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据