4.6 Review

Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Roles of PTEN (Phosphatase and Tensin Homolog) in Gastric Cancer Development and Progression

Wen-Ting Xu et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2014)

Article Biochemistry & Molecular Biology

MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA

Yihui Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

Yong Gao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Oncology

Temsirolimus enhances the efficacy of cetuximab in colon cancer through a CIP2A-dependent mechanism

Hsei-Wei Wang et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2014)

Article Oncology

PTEN Is a Potent Suppressor of Small Cell Lung Cancer

Min Cui et al.

MOLECULAR CANCER RESEARCH (2014)

Review Biotechnology & Applied Microbiology

PI3K and cancer: lessons, challenges and opportunities

David A. Fruman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

PTEN is a protein tyrosine phosphatase for IRS1

Yuji Shi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma

Xiaowei Guan et al.

PLOS ONE (2014)

Review Biochemistry & Molecular Biology

PTEN function: the long and the short of it

Benjamin D. Hopkins et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Article Oncology

Targeting EGFR and PI3K pathways in ovarian cancer

S. Glaysher et al.

BRITISH JOURNAL OF CANCER (2013)

Article Genetics & Heredity

A mosaic PTEN mutation causing Cowden syndrome identified by deep sequencing

Colin C. Pritchard et al.

GENETICS IN MEDICINE (2013)

Article Endocrinology & Metabolism

Targeted Next-Generation Sequencing Panel (ThyroSeq) for Detection of Mutations in Thyroid Cancer

Marina N. Nikiforova et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Oncology

A phase I study of ridaforolimus in adult Chinese patients with advanced solid tumors

Lian Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2013)

Review Oncology

MDM2, MDMX and p53 in oncogenesis and cancer therapy

Mark Wade et al.

NATURE REVIEWS CANCER (2013)

Article Biochemistry & Molecular Biology

MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA

Qingbo Lang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Biochemical Research Methods

A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines

Luke B. Hesson et al.

BIOLOGICAL PROCEDURES ONLINE (2012)

Article Oncology

Phase II trial of temsirolimus in patients with metastatic breast cancer

Gini F. Fleming et al.

BREAST CANCER RESEARCH AND TREATMENT (2012)

Review Pharmacology & Pharmacy

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

Antonella De Luca et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

Review Dermatology

Cutaneous T cell lymphoma: update on treatment

Uwe Wollina

INTERNATIONAL JOURNAL OF DERMATOLOGY (2012)

Review Biotechnology & Applied Microbiology

Combinatorial drug therapy for cancer in the post-genomic era

Bissan Al-Lazikani et al.

NATURE BIOTECHNOLOGY (2012)

Article Oncology

Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells

Nguyen Thi Thuy Phuong et al.

BREAST CANCER RESEARCH AND TREATMENT (2011)

Article Oncology

PI3K Pathway Mutations and PTEN Levels in Primary and Metastatic Breast Cancer

Ana M. Gonzalez-Angulo et al.

MOLECULAR CANCER THERAPEUTICS (2011)

Article Multidisciplinary Sciences

The genomic complexity of primary human prostate cancer

Michael F. Berger et al.

NATURE (2011)

Article Endocrinology & Metabolism

Frequency of Germline PTEN Mutations in Differentiated Thyroid Cancer

Rebecca Nagy et al.

THYROID (2011)

Review Cell Biology

Targeting the PI3K signaling pathway in cancer

Kwok-Kin Wong et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2010)

Review Pharmacology & Pharmacy

Akt inhibitors in clinical development for the treatment of cancer

Sumanta Kumar Pal et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)

Article Oncology

PTEN mutation spectrum in breast cancers and breast hyperplasia

JuLun Yang et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)

Review Oncology

The PI3K Pathway As Drug Target in Human Cancer

Kevin D. Courtney et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Article Oncology

Phase II Trial of Gefitinib and Everolimus in Advanced Non-small Cell Lung Cancer

Katharine A. Price et al.

JOURNAL OF THORACIC ONCOLOGY (2010)

Review Biochemistry & Molecular Biology

Inhibitors of phosphatidylinositol-3-kinase in cancer therapy

Nathan T. Ihle et al.

MOLECULAR ASPECTS OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling

A. H. Beck et al.

ONCOGENE (2010)

Article Oncology

PIK3CA mutations and copy number gains in human lung cancers

Hiromasa Yamamoto et al.

CANCER RESEARCH (2008)

Article Endocrinology & Metabolism

Phosphatidylinositol 3-Kinase/Akt and Ras/RafMitogen-Activated protein kinase pathway mutations in anaplastic thyroid cancer

Libero Santarpia et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Article Biochemistry & Molecular Biology

AKT1E17K in human solid tumours

F. E. Bleeker et al.

ONCOGENE (2008)

Article Pathology

PIK3CA mutation and amplification in human lung cancer

Koji Okudela et al.

PATHOLOGY INTERNATIONAL (2007)

Article Medicine, General & Internal

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

Gary Hudes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Gastroenterology & Hepatology

Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma

Li Wang et al.

HEPATOLOGY RESEARCH (2007)

Article Endocrinology & Metabolism

High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/Akt pathway in thyroid tumors

Yangang Wang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

Article Clinical Neurology

PIK3CA alterations in primary (de novo) and secondary glioblastomas

Daisuke Kita et al.

ACTA NEUROPATHOLOGICA (2007)

Article Oncology

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme

Gary L. Gallia et al.

MOLECULAR CANCER RESEARCH (2006)

Review Biotechnology & Applied Microbiology

Exploiting the PI3K/AKT pathway for cancer drug discovery

BT Hennessy et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Oncology

Frequent mutation of the PIK3CA gene in ovarian and breast cancers

DA Levine et al.

CLINICAL CANCER RESEARCH (2005)

Article Biochemistry & Molecular Biology

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas

JW Lee et al.

ONCOGENE (2005)

Article Gastroenterology & Hepatology

Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions

Yi-Ling Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

Article Multidisciplinary Sciences

High frequency of mutations of the PIK3CA gene in human cancers

Y Samuels et al.

SCIENCE (2004)

Article Oncology

The biology and clinical relevance of the PTEN tumor suppressor pathway

I Sansal et al.

JOURNAL OF CLINICAL ONCOLOGY (2004)

Article Oncology

PTEN promoter is methylated in a proportion of invasive breast cancers

S Khan et al.

INTERNATIONAL JOURNAL OF CANCER (2004)

Review Oncology

The phosphatidylinositol 3-kinase-AKT pathway in human cancer

I Vivanco et al.

NATURE REVIEWS CANCER (2002)

Article Multidisciplinary Sciences

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

B Kwabi-Addo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)