期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 140, 期 1, 页码 1-14出版社
SPRINGER
DOI: 10.1007/s00432-013-1494-1
关键词
Tumor-acquired resistance; NF-kappa B; HER2; STAT3; Breast cancer stem cells
类别
资金
- National Institutes of Health [CA133402, CA152313]
The lethal effects of cancer are associated with the enhanced tumor aggressiveness in recurrent and metastatic lesions that show resistant phenotype to anti-cancer therapy, a major barrier to improving overall survival of cancer patients. The presence of heterogeneous populations of cancer cells within a specific tumor including the tumor-initiating cells or so-called cancer stem cells (CSCs) has linked the acquired resistance (AR, or adaptive resistance). Herein, we discuss the CSC-mediated tumor repopulation in AR of breast cancer in this review. We emphasize a dynamic feature of gene induction in tumor cells that undergo long-term treatment, and describe a specific HER2-NF-kappa B-HER2 pro-survival pathway that can be initiated in breast CSCs upon radiation therapy. Elucidation of HER2-induced pro-survival networks, specifically the force driving tumor repopulation due to radioresistant CSCs during anticancer therapies, will have a significant impact on the generation of new diagnostic and therapeutic targets to control of recurrent and metastatic breast tumors.
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