期刊
NEUROBIOLOGY OF AGING
卷 36, 期 9, 页码 2577-2586出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2015.05.014
关键词
Slow-wave sleep; Aging; Electrical stimulation; Declarative memory
资金
- Bright Focus Foundation
- American Health Assistance Foundation
- Alzheimer's Association
- Illinois Department of Public Health Alzheimer's Disease Research Fund
- National Institute on Aging [P01 AG11412]
- German Ministry of Education and Research Grant [01GQ1008]
- Northwestern University Cognitive Neurology and Alzheimer's Disease Center, including a Pilot Project Grant Award [NIH P30 AG13854]
- Alzheimer's Disease Research
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [1461088] Funding Source: National Science Foundation
We examined the intriguing but controversial idea that disrupted sleep-dependent consolidation contributes to age-related memory decline. Slow-wave activity during sleep may help strengthen neural connections and provide memories with long-term stability, in which case decreased slow-wave activity in older adults could contribute to their weaker memories. One prediction from this account is that age-related memory deficits should be reduced by artificially enhancing slow-wave activity. In young adults, applying transcranial current oscillating at a slow frequency (0.75 Hz) during sleep improves memory. Here, we tested whether this procedure can improve memory in older adults. In 2 sessions separated by 1 week, we applied either slow-oscillatory stimulation or sham stimulation during an afternoon nap in a double-blind, crossover design. Memory tests were administered before and after sleep. A larger improvement in word-pair recall and higher slow-wave activity was observed with slow-oscillatory stimulation than with sham stimulation. This is the first demonstration that this procedure can improve memory in older adults, suggesting that declarative memory performance in older adults is partly dependent on slow-wave activity during sleep. (C) 2015 Elsevier Inc. All rights reserved.
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