期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 138, 期 1, 页码 85-93出版社
SPRINGER
DOI: 10.1007/s00432-011-1068-z
关键词
microRNAs; Non-small-cell lung cancer; Stem-loop RT-PCR; Biomarker
类别
资金
- Jiangsu Provincial Scientific Committee
- Health Department
- Kejiaoxingwei Project [KF200939]
Purpose To investigate the levels for some specified microRNAs in human's peripheral blood so as to determine whether they can serve as biomarkers for metastatic non-small-cell lung cancer. Methods Use a quantitative stem-loop RT-PCR method to examine the serum levels for certain microRNAs including has-miR-125a-5p, has-miR-126, has-miR-183, has-miR-200, has-miR-221, and has-miR-222 from the patients with Stage IV, Stage I/II non-small-cell lung cancer and the controls. Results There was statistical difference in the serum levels for hsa-miR-126, hsa-miR-183, and hsa-miR-222 between the controls and the Stage IV patients, but not for has-miR125a-5p, has-miR-200 and has-miR-221. It also showed statistical difference for hsa-miR-126 and hsa-miR-183 between the Stage I/II patients and Stage IV patients, but not between the controls and Stage I/II patients. Conclusion Hsa-miR-126 and hsa-miR-183 may serve as potential serum biomarkers for metastatic non-small-cell lung cancer.
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