期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 136, 期 5, 页码 639-650出版社
SPRINGER
DOI: 10.1007/s00432-010-0792-0
关键词
IGF-1R targeted therapy; Chemotherapy; Chemoresistance; Combination cancer therapy
类别
Chemotherapy is administered only to patients with advanced cancers, typically to modest avail. Hence, the search for innovative approaches to treat cancer is growing rapidly. One such approach involves targeting molecular pathways identified as encouraging tumor growth and maintenance, particularly the type 1 insulin-like growth factor (IGF-1) and its receptor (IGF-1R) pathway that is important in conferring chemoresistance. This study focuses on IGF-1R targeted therapy, which will enhance chemotherapy efficacy, through reviewing recent literature from PubMed and Medline databases. This review examines data and strategies addressing an approach conquering chemoresistance through the combination of IGF-1R targeted therapy and chemotherapy in cancer patients, as well as the mechanisms by which IGF-1R acts as a target. This will impact on future research on treatment selection, thereby improving patient prognosis.
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