期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 135, 期 10, 页码 1403-1412出版社
SPRINGER
DOI: 10.1007/s00432-009-0584-6
关键词
Hepatocellular carcinoma; Liver transplantation; Criteria; Prognosis
类别
资金
- National Natural Science Foundation of China [30873039, 30571801]
- Shanghai Science and Technology Development Funds [06QA14012, 054119530]
- Foundation of Shanghai Science Technology Commission [07JC14010, 06xD14004, 044119608, 07SP07003]
- National Key Sci-Tech Special Project of China [2008ZX10002-022]
- Program for Excellent Disciplinary Leaders of Shanghai Health Bureau [LJ06004]
To evaluate current selection criteria for patients undergoing liver transplantation (LT) in response to hepatocellular carcinoma (HCC), and to analyze the prognostic factors for successful transplantation. We evaluated the outcome of 1,078 consecutive patients with HCC from the Shanghai Multi-Center Collaborative LT Group who underwent LT over a 6-year period. Clinicopathologic data for these patients were evaluated. The prognostic significance was assessed using Kaplan-Meier survival estimates and log-rank tests. Multivariate study with Cox's proportional hazard model was used to evaluate the prognosis-relative aspects. We determined that expansion of Milan criteria to include: a solitary lesion a parts per thousand currency sign9 cm in diameter, no more than three lesions with the largest a parts per thousand currency sign5 cm, a total tumor diameter a parts per thousand currency sign9 cm without macrovascular invasion, lymph node invasion and extrahepatic metastasis (referred to as the Shanghai criteria), resulted in overall survival (OS) and disease-free survival (DFS) rates that were similar to the Milan criteria. Multivariate analysis using the Cox proportional hazards regression model showed that the Child-Pugh-Turcotte classification (P = 0.010, 0.000), tumor differentiation (P = 0.001, 0.000), tumor size (P = 0.000, 0.000) and number (P = 0.014, 0.016), macrovascular invasion (P = 0.022, 0.000) and alpha-fetoprotein (AFP) levels (P = 0.031, 0.003) were independent predictors of OS and DFS, while post-LT chemotherapy (OS, P = 0.000) and tumor encapsulation (DFS, P = 0.038) were independent predictors of OS or DFS. Shanghai criteria expanded the current criteria while maintaining similar survival.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据