期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 135, 期 12, 页码 1711-1716出版社
SPRINGER
DOI: 10.1007/s00432-009-0618-0
关键词
Non-Hodgkin's lymphoma; Family history; Histology; Survival; Hazard ratio
类别
资金
- Deutsche Krebshilfe
- Swedish Cancer Society
- EU [LSHC-CT-2004-503465]
- Swedish Council for Working Life and Social Research
Although survival has been studied for various subtypes of non-Hodgkin's lymphoma (NHL), there have been few comprehensive studies to quantify the prognosis, including all specific histologies. The effect of family history on survival in NHL has not been examined. We used the Swedish Family-Cancer Database to estimate hazard ratios in NHL by histology and family history. Using diffuse centroblastic lymphoma as reference (HR 1.0), patients with Waldenstrom's macroglobulinemia and hairy-cell leukemia had the best survival. Survival advantage was also noted among patients with lymphoplasmacytic lymphoma and different kinds of follicular lymphomas. For T-cell lymphoma, mycosis fungoides showed a favorable prognosis. As for survival by family history, a total of 98 familial cases were noted in our Database with a similar prognosis compared to sporadic cases in both parental and offspring generations. A non-significant familial concordance of either good or poor survival was noted among family members when probands' prognosis was stratified by survival time. Our results provide quantitative prognosis data for patients with NHL according to specific histologies. Patients with a familial NHL had a similar prognosis compared to patients with sporadic disease. The data suggest familial concordance in either good or poor survival among family members.
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