期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 135, 期 3, 页码 355-363出版社
SPRINGER
DOI: 10.1007/s00432-008-0481-4
关键词
Galectin-3; Hemagglutination; Creatinine; Metastasis; Radio/chemotherapy; Urine
类别
资金
- Department of Biotechnology, New Delhi, India
- Department of Science and Technology, New Delhi, India
- Indian Council of Medical Research
Galectin-3 has been implicated in advanced stage of cancer disease. In the current study we examined the possibility of urinary galectin-3 levels to stage cancer disease and to follow up therapy. Urine was collected from all types of cancer patients at different stages including patients undergoing radio/chemotherapy. Galectin-3 level was determined by anti-galectin-3 based ELISA and agglutination assays. Immunoblotting and purification on lactosyl affinity column further confirmed the presence of galectin-3. Cancer samples exhibited stage dependent expression of galectin-3 approx. ranging from 1.0 to 3.3, 4.4 to 5.4, 5.4 to 24.7, 13.1 to 31.9, 13.9 to 32.9 ng/mg C (creatinine) for stage I-V, respectively, at P < 0.05 level. Galectin-3 levels were decreased by approx. threefolds after 5th day of therapy. Sample collection being simple and non-invasive, urinary galectin-3 may be used as a potential diagnostic tool for monitoring or follow up of the stage of cancer disease.
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