期刊
NEUROBIOLOGY OF AGING
卷 36, 期 -, 页码 S32-S41出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.03.044
关键词
Biomarkers; Alzheimer's disease; Mild cognitive impairment; Brain imaging; Magnetic resonance imaging (MRI); Cortical; Gray matter; Thickness; Volume; Surface area; Brain structure; Longitudinal
资金
- National Defense Science and Engineering Graduate (NDSEG) Fellowship from the U.S. Department of Defense [32 CFR 168a]
- Air Force Office of Scientific Research
- National Institute of Biomedical Imaging and Bioengineering [R01 EB008281, R01 EB008432]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Mental Health
- U.S. National Library of Medicine
- National Center for Research Resources [AG016570, AG040060, EB01651, MH097268, LM05639, RR019771]
- ADNI (National Institutes of Health) [U01 AG024904]
- Abbott
- Alzheimer's Association
- Alzheimer Drug Discovery Foundation
- Amorfix Life Sciences Ltd
- AstraZeneca
- Bayer Healthcare
- Bio-Clinica, Inc
- Biogen Idec Inc
- Bristol-Myers Squibb Foundation
- Eisai
- Elan Pharmaceuticals Inc
- Eli Lilly and Company
- F. Hoffmann-La Roche Ltd
- Genentech, Inc
- GE Healthcare
- Innogenetics, N.V.
- IXICO Ltd
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson & Johnson Pharmaceutical Research & Development LLC
- Medpace, Inc
- Merck Co, Inc
- Meso Scale Diagnostics, LLC
- Novartis Pharmaceuticals Corporation
- Pfizer
- Servier
- Synarc Inc
- Takeda Pharmaceuticals North America
- Canadian Institutes of Health Research
- National Institutes of Health from the National Institute of General Medical Sciences [P30 AG010129, K01 AG030514]
Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct role in cognition, ventricular expansion co-occurs with volumetric loss in gray and white matter structures. To better understand relationships between ventricular and cortical changes over time, we related ventricular expansion to atrophy in cognitively relevant cortical gray matter surfaces, which are more challenging to segment. In ADNI participants, percent change in ventricular volumes at 1-year (N = 677) and 2-year (N = 536) intervals was significantly associated with baseline cortical thickness and volume in the full sample controlling for age, sex, and diagnosis, and in MCI separately. Ventricular expansion in MCI was associated with thinner gray matter in frontal, temporal, and parietal regions affected by AD. Ventricular expansion reflects cortical atrophy in early AD, offering a useful biomarker for clinical trials of interventions to slow AD progression. (C) 2015 Elsevier Inc. All rights reserved.
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