期刊
JOURNAL OF BURN CARE & RESEARCH
卷 34, 期 6, 页码 633-638出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BCR.0b013e318280e2f8
关键词
-
资金
- National Institute of Health [R01AA015731, F30AA020167]
- Dr. Ralph and Marian C. Falk Medical Research Trust
Intestinal inflammation has been linked with multiorgan failure in patients with burn and other traumatic injuries. We hypothesized that markers of intestinal inflammation are detectible noninvasively. Fecal samples were collected from seven severely burned patients and 15 control patients for the measurement of inflammatory cytokines using a multiplex assay kit. In addition, fecal levels of myeloperoxidase (MPO) and elastase were measured using standard procedures. Compared with a control group, levels of inflammatory cytokines were significantly increased in the burn group. Interleukin (IL)-6 increased to a mean (+/- SEM) of 2.16 +/- 0.61 to 3.81 +/- 0.49 pg/mg (P < .05), as did IL-8 (3.32 +/- 0.76 to 20.51 +/- 6.65 pg/mg; P < .05), IL-12 (6.23 +/- 0.98 to 8.11 +/- 0.95pg/mg; P=0.01), IL-13 (3.86 +/- 0.32 to 11.83 +/- 1.47 pg/mg; P < .05), monocyte chemoattractant protein-1 (2.78 +/- 2.61 to 6.5 +/- 3.97 pg/mg; P < .05), MPO (13.41 +/- 1.40 to 24.52 +/- 4.31 units/mg protein; P < .05), and elastase (2.46 +/- 0.38 to 5.08 +/- 0.72 pg/mL; P < .05). Our results suggest that markers of intestinal inflammation are measurable by noninvasive means and are increased after burn injury compared with controls. Of note, increased IL-8 correlated with increased MPO and elastase activity, suggesting a role for neutrophil activation in burn-mediated intestinal inflammation. Thus, these inflammatory cytokine profiles may be valuable biomarkers of intestinal inflammation after burn injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据