期刊
NEUROBIOLOGY OF AGING
卷 36, 期 3, 页码 1239-1244出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.12.008
关键词
Beta-amyloid; Apolipoprotein E; Cognitive decline; Preclinical Alzheimer's disease; Memory
资金
- Australian Commonwealth Scientific Industrial and research Organization (CSIRO)
- Edith Cowan University (ECU)
- Mental Health Research Institute (MHRI)
- Alzheimer's Australia (AA)
- National Ageing Research Institute (NARI)
- Austin Health
- CogState Ltd.
- Hollywood Private Hospital
- Sir Charles Gardner Hospital
- National Health and Medical Research Council (NHMRC)
- Dementia Collaborative Research Centres program (DCRC2)
- Science and Industry Endowment Fund (SIEF)
- Cooperative Research Centre (CRC) for Mental Health, from the Australian Government
The apolipoprotein E (APOE) epsilon 4 allele and high levels of beta-amyloid (A beta) are associated with episodic memory decline and risk for Alzheimer's disease. However, there is debate about independent or interactive effects of epsilon 4 on A beta-related memory decline in healthy older adults. Healthy older adults with high A beta burden (n = 84) enrolled in Australian Imaging, Biomarkers, and Lifestyle Study were included in this study. Cognition was measured using the computerized Cogstate Brief Battery at baseline, 18-, 36-, and 54-month follow-ups. Mini Mental State Examination and Clinical Dementia Rating scales were also administered at baseline and each follow-up timepoint. Relative to A beta + epsilon 4 noncarriers (n - 36), A beta + epsilon 4 carriers (n = 48) showed significantly faster decline on memory tasks, which was by convention, moderate in magnitude (d = 0.40-0.47). A beta positivity coupled with APOE epsilon 4 was associated with moderately increased decline in memory over a 54-month assessment period, suggesting that, in the preclinical stages of Alzheimer's disease, the manifestation of memory decline in older adults with high A beta is exacerbated by the presence of APOE epsilon 4. (C) 2015 Elsevier Inc. All rights reserved.
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